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Omeprazole
FDA Approved
Membrane IntercalationOral
Description
Omeprazole is a proton pump inhibitor that reduces stomach acid production. It requires membrane penetration and accumulation in acidic compartments to reach its target enzyme.
Chemical Properties
Molecular FormulaC17H19N3O3S
Molecular Weight345.4 g/mol
Oral Bioavailability40%
CAS Number73590-58-6
DrugBank IDDB00338
PubChem CID4594
SMILES
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=CC(=C3)OC
Membrane Intercalation Mechanism
Proton pump inhibitors accumulate in acidic canaliculi of parietal cells, where they intercalate and covalently bind to H+/K+-ATPase in the membrane.