Back to Drugs
Itraconazole
FDA Approved
Membrane IntercalationOral
Description
Itraconazole is a triazole antifungal that works by inhibiting ergosterol synthesis in fungal cell membranes, affecting membrane integrity and permeability.
Chemical Properties
Molecular FormulaC35H38Cl2N8O4
Molecular Weight705.6 g/mol
Oral Bioavailability55%
CAS Number84625-61-6
DrugBank IDDB01167
PubChem CID55283
SMILES
CCC(C)N1N=CN=C1CN(C)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Membrane Intercalation Mechanism
Azole antifungals intercalate into fungal cell membranes and inhibit ergosterol synthesis, disrupting membrane structure and function.