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Chloroquine
FDA Approved
Membrane IntercalationOral
Description
Chloroquine is an antimalarial and antirheumatic drug. Its membrane intercalation properties contribute to its ability to accumulate in lysosomes and affect intracellular pH.
Chemical Properties
Molecular FormulaC18H26ClN3
Molecular Weight319.9 g/mol
Oral Bioavailability89%
CAS Number54-05-7
DrugBank IDDB00608
PubChem CID2719
SMILES
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Membrane Intercalation Mechanism
Chloroquine is a weak base that accumulates in acidic compartments and intercalates into lipid membranes, particularly affecting membrane permeability and fluidity.