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Ciprofloxacin
FDA Approved
Membrane IntercalationOral
Description
Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV. Its ability to penetrate bacterial membranes contributes to its broad-spectrum activity.
Chemical Properties
Molecular FormulaC17H18FN3O3
Molecular Weight331.3 g/mol
Oral Bioavailability70%
CAS Number85721-33-1
DrugBank IDDB00537
PubChem CID2764
SMILES
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O
Membrane Intercalation Mechanism
Fluoroquinolones like ciprofloxacin can intercalate into lipid bilayers due to their amphiphilic nature, with the fluorine and carbonyl groups interacting with membrane components.