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Simvastatin
FDA Approved
Membrane IntercalationOral
Description
Simvastatin is a statin used to lower cholesterol levels. As a prodrug, it requires membrane transport and intracellular activation to inhibit cholesterol synthesis.
Chemical Properties
Molecular FormulaC25H38O5
Molecular Weight418.6 g/mol
Oral Bioavailability5%
CAS Number79902-63-9
DrugBank IDDB00641
PubChem CID54454
SMILES
CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
Membrane Intercalation Mechanism
Simvastatin is a prodrug that becomes active after membrane uptake and intracellular hydrolysis, allowing interaction with membrane-bound HMG-CoA reductase.