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Amlodipine
FDA Approved
Membrane IntercalationOral
Description
Amlodipine is a dihydropyridine calcium channel blocker used to treat hypertension. It works by binding to calcium channels embedded in vascular smooth muscle cell membranes.
Chemical Properties
Molecular FormulaC20H25ClN2O5
Molecular Weight408.9 g/mol
Oral Bioavailability64%
CAS Number88150-42-9
DrugBank IDDB00381
PubChem CID2162
SMILES
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Membrane Intercalation Mechanism
Dihydropyridine calcium channel blockers like amlodipine bind to L-type calcium channels within cell membranes, modulating calcium influx through membrane interaction.