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Fluoxetine
FDA Approved
Membrane IntercalationOral
Description
Fluoxetine (Prozac) is an SSRI antidepressant that selectively inhibits serotonin reuptake. Its membrane-active properties are crucial for CNS penetration and transporter binding.
Chemical Properties
Molecular FormulaC17H18F3NO
Molecular Weight309.3 g/mol
Oral Bioavailability72%
CAS Number54910-89-3
DrugBank IDDB00472
PubChem CID3386
SMILES
CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
Membrane Intercalation Mechanism
Fluoxetine's trifluoromethyl group and aromatic rings facilitate membrane insertion and interaction with serotonin transporters embedded in neuronal membranes.