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Sertraline
FDA Approved
Membrane IntercalationOral
Description
Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Its lipophilic properties enable crossing of the blood-brain barrier and membrane integration at synaptic sites.
Chemical Properties
Molecular FormulaC17H17Cl2N
Molecular Weight306.2 g/mol
Oral Bioavailability44%
CAS Number79617-96-2
DrugBank IDDB01104
PubChem CID68617
SMILES
CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Membrane Intercalation Mechanism
SSRIs like sertraline are lipophilic molecules that readily partition into neuronal cell membranes, allowing access to membrane-bound serotonin reuptake transporters.