Back to Drugs
Atorvastatin
FDA Approved
Membrane IntercalationOral
Description
Atorvastatin is a statin used to lower cholesterol. Its ability to penetrate cell membranes is essential for reaching its target enzyme in the endoplasmic reticulum.
Chemical Properties
Molecular FormulaC33H35FN2O5
Molecular Weight558.6 g/mol
Oral Bioavailability14%
CAS Number134523-00-5
DrugBank IDDB01076
PubChem CID60823
SMILES
CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
Membrane Intercalation Mechanism
Statins are amphipathic molecules that partition into lipid membranes and interact with membrane-bound HMG-CoA reductase, affecting membrane cholesterol synthesis.